Looking for the perfect girls weekend getaway from St. Louis? Whether you’re seeking a fun city escape, scenic outdoor adventures, or a relaxing retreat to unwind with your best friends, you don’t need to travel far. Since Missouri is located in the center of the United States, St. Louis is surrounded by amazing destinations that offer everything you need for an unforgettable weekend. From charming small towns to lively cities, you’ll find plenty of budget-friendly options that promise great food, unique experiences, and plenty of memories.
No matter if you’re planning a weekend getaway for a birthday celebration, a reunion with your college crew, or simply to escape the hustle and bustle of everyday life, these easy girls weekend trips are the perfect mix of adventure and relaxation. With quick weekend trips from St. Louis, you can enjoy great food, live music, and even some wine tasting in Missouri’s best spots, all within a short drive.
Let’s dive into these top destinations that make for the ultimate girls’ weekend!
1. Hermann, Missouri
Hermann, Missouri, is one of the most charming small towns near St. Louis and an ideal girls weekend getaway. Nestled in the rolling hills of Missouri wine country, Hermann offers a perfect blend of relaxing retreats, wine tasting, and scenic viewsnmaking it an unforgettable destination for a girls’ trip. Whether you’re into exploring historic sites, indulging in local wines, or just relaxing with your best friends, this affordable destination is packed with fun activities for everyone.
There is no better way to spend a great weekend getaway than with your friends, staying in a cute boutique hotel in Hermann, and drinking wine and enjoying delicious food every day! Check out my guide to the best hotels in Hermann and also my guide to the best restaurants in Hermann!
Why Hermann is Perfect for a Girls Weekend Trip
Hermann feels like stepping into a cozy European town, with its cobblestone streets and historic architecture. The town is home to numerous vineyards, which makes it a great place for wine lovers to unwind. If you’re looking to relax, you’ll love the small-town vibe and the abundance of charming bed and breakfasts that cater to group getaways. The peaceful Missouri River adds to the town’s tranquil atmosphere, making it an excellent spot for quality time with your best friends.
For a weekend trip full of great food, fun wine-tasting experiences, and easy walkable access to local attractions, Hermann is an amazing girls weekend destination.
Top Things to Do in Hermann
- Wine Tasting Tour: Hermann is home to several award-winning wineries. The Hermann Wine Trail offers a self-guided tour of the local wineries, where you can sample Missouri’s best wines and learn about the region’s wine-making history. Check out my list of the best Missouri wineries here!
- Hike the Katy Trail: If you’re looking for outdoor fun, the Katy Trail offers scenic walking and biking paths along the Missouri River. It’s a perfect spot for enjoying nature and spending time outdoors with your friends.
- Explore Historic Downtown Hermann: Stroll through downtown to admire the beautifully preserved 19th-century buildings and enjoy quaint shops, antique stores, and local art galleries. Don’t miss the chance to stop by Hermannhof Winery or Stone Hill Winery for a wine-tasting experience.
- Visit the German Heritage Museum: Learn about Hermann’s German roots at this small but fascinating museum, offering a peek into the town’s history and culture.
- Relax at a Local Spa: After a day of wine tasting and sightseeing, treat yourself to a relaxing spa day. Hermann has several spas offering group-friendly packages, ideal for a relaxing weekend getaway.
2. Columbia, Missouri
If you’re looking for a vibrant yet affordable girls weekend getaway, Columbia, Missouri, offers the perfect mix of college town energy, outdoor activities, and great food. Home to the University of Missouri, Columbia boasts a lively atmosphere with numerous shops, breweries, and outdoor spaces that make it a fantastic girls trip destination. Whether you’re into exploring local parks, enjoying live music, or visiting unique shops, Columbia has something for every group.
Why Columbia is Perfect for a Girls Weekend Trip
Columbia’s dynamic downtown area is packed with coffee shops, art galleries, and boutique stores, making it ideal for a fun and relaxed weekend. With its easy access to state parks, as well as its vibrant nightlife scene, this destination has the best of both worlds. Columbia is also known for its rich cultural history and commitment to local food, offering an authentic experience you won’t find anywhere else. It’s the perfect place for an unforgettable weekend with good friends.
Top Things to Do in Columbia
- Shop at the Columbia Mall and Local Boutiques: If your group loves shopping, you’ll enjoy strolling through Columbia’s trendy boutiques and local shops. Make sure to visit The District, Columbia’s historic downtown area, filled with unique stores and charming cafes.
- Explore Rock Bridge Memorial State Park: If you’re looking for outdoor activities, this state park is a must-visit. You can hike the Gans Creek Wild Area or explore the famous Rock Bridge itself for beautiful views and a peaceful retreat.
- Catch a Show at The Blue Note: Columbia has an amazing live music scene, and The Blue Note is one of the best venues in town. Whether it’s a local band or a national act, this venue provides a lively atmosphere perfect for a night out with friends.
- Visit the Mizzou Botanic Garden: For a relaxing stroll, head to the Mizzou Botanic Garden on the University of Missouri campus. This hidden gem offers beautiful flower gardens and peaceful spaces to sit and enjoy nature.
- Grab Drinks at Local Breweries: Columbia has several fantastic local breweries like Logboat Brewing Company and Boulevard Brewing Company. These spots offer a great time for you and your friends to unwind with locally crafted beer in a fun and relaxed setting.
3. Hannibal, Missouri
Hannibal, Missouri, is a charming small town located on the banks of the Mississippi River and is the perfect spot for a girls weekend getaway. With its rich history, picturesque views, and plenty of outdoor activities, Hannibal combines a relaxed vibe with fun, making it a top pick for a great girls trip. Known as the home of Mark Twain, the town offers a mix of cultural experiences and unique activities that are sure to make your girls weekend memorable.
Why Hannibal is Perfect for a Girls Weekend Trip
Hannibal’s small town charm and historical significance set it apart from the usual girls trip destinations. With its quaint streets lined with historic homes, art galleries, and antique shops, it’s an ideal place for strolling and soaking in the beauty of the town. Hannibal also boasts some incredible outdoor recreation options along the Mississippi River, offering a laid-back atmosphere to unwind and reconnect with your best friends.
Top Things to Do in Hannibal
- Tour the Mark Twain Boyhood Home & Museum: Dive into literary history by visiting the Mark Twain Boyhood Home, where the famous author spent his early years. It’s one of the most popular things to do in Hannibal and a must for fans of classic American literature.
- Cruise on the Mississippi River: For a unique experience, hop on a Mississippi River cruise to explore the scenic river from a boat. Whether it’s a casual afternoon cruise or a dinner boat ride, this activity is a great way to relax and enjoy panoramic views with your group.
- Explore Historic Main Street: Walk along Hannibal’s Main Street, where you’ll find antique stores, local shops, and cozy cafes. It’s a perfect place to spend the day browsing for unique finds or grabbing a bite to eat with friends.
- Visit the Hannibal Cave: If your group loves outdoor adventure, take a guided tour of the Hannibal Cave. It’s a fun and affordable way to explore the area’s natural beauty, with plenty of opportunities for unique photos along the way.
- Relax at Riverview Park: For some quiet time, head to Riverview Park where you can enjoy a leisurely walk, have a picnic, or simply take in the views of the Mississippi River. It’s a peaceful spot to unwind after a busy day of exploring.
4. Shawnee National Forest, Illinois
For a nature-filled girls weekend escape, Shawnee National Forest in southern Illinois is an excellent choice. This stunning natural area is perfect for outdoor enthusiasts, offering a wide variety of activities like hiking, camping, and exploring scenic trails. If you’re looking for affordable getaways that still offer an abundance of things to do, Shawnee is one of the best places to enjoy quality time with your best friends, surrounded by the beauty of state parks and wildlife.
Why Shawnee National Forest is Perfect for a Girls Weekend Trip
Shawnee National Forest provides a unique combination of tranquility and adventure. With lakes, canyons, and waterfalls, it’s an ideal location for outdoor activities like hiking and horseback riding, while also offering plenty of opportunities for relaxation. Whether you’re planning a long weekend or just a quick getaway, Shawnee’s easy access from St. Louis makes it a convenient destination for those looking to escape into nature without having to travel too far.
Top Things to Do in Shawnee National Forest
- Hike the Garden of the Gods: One of the top attractions in Shawnee, the Garden of the Gods offers breathtaking panoramic views of rock formations and scenic landscapes. It’s a perfect spot for a photo op and a great way to enjoy some outdoor adventure with your friends.
- Take a Boat Ride on the Ohio River: The Ohio River offers a peaceful setting for a relaxing boat ride. Rent a boat or hop on a scenic river cruise to explore the area from the water, taking in views of the forest and nearby bluffs.
- Visit the Iron Furnace: Step back in time and visit the Iron Furnace, an important historical landmark from the 19th century. It’s a fascinating spot to explore with friends while learning about the history of the region.
- Go Horseback Riding: If your group loves outdoor activities, consider booking a horseback riding tour. Shawnee National Forest offers scenic horseback trails through some of the most beautiful parts of the forest.
- Relax at Lake of Egypt: This beautiful lake is a great spot for a low-key day with your friends. Rent a boat, enjoy a swim, or simply relax by the water and enjoy the serene surroundings.
5. Branson, Missouri
Branson, Missouri, is the ultimate destination for a girls weekend filled with entertainment, outdoor fun, and relaxation. Nestled in the beautiful Ozarks, Branson offers everything from world-class live shows to scenic lakeside views. Whether you’re in the mood for shopping, outdoor adventures, or relaxing by the lake, Branson has something for everyone. Plus, its easy access from St. Louis makes it a perfect weekend getaway.
Why Branson is Perfect for a Girls Weekend Trip
Branson is one of the best destinations for a girls weekend and it is only about a 4 hour drive from the Gateway Arch! With its live music, vibrant shows, and scenic beauty in the great outdoors, Branson is the perfect mix of excitement and relaxation. Whether you’re looking for a weekend filled with shopping, a road trip through the Ozarks, or a weekend getaway by the lake, Branson has it all. With its proximity to St. Louis, it’s an easy, affordable trip that promises great memories. Spring Break is a great time to visit branson!
Top Things to Do in Branson
- Catch a Live Show: Branson is famous for its live entertainment scene. From country music to Broadway-style performances, there’s something for everyone. The Sight & Sound Theatre and Silver Dollar City offer incredible performances that will leave you in awe.
- Explore Table Rock Lake: If your group loves outdoor activities, Table Rock Lake offers plenty of opportunities for fun. You can rent a boat, go fishing, or simply relax by the water and take in the stunning views.
- Shop at Branson Landing: Branson Landing is the place to go for some retail therapy. With its charming shops, delicious restaurants, and picturesque views of Lake Taneycomo, it’s the perfect spot to spend an afternoon shopping and enjoying the atmosphere.
- Hike at Ozark Mountain State Park: If you’re looking for a bit of adventure, head to Ozark Mountain State Park. The park offers scenic trails with breathtaking views, making it the perfect spot for a nature-filled day with your best friends.
- Relax at Big Cedar Lodge: For a more laid-back day, treat your group to some relaxation at Big Cedar Lodge. Enjoy the peaceful atmosphere, spa treatments, and stunning views of the Ozarks at this beautiful resort.
6. Lake of the Ozarks, Missouri
If you’re looking for a girls’ weekend where you can kick back and enjoy great food, refreshing drinks, and outdoor fun, Lake of the Ozarks is the perfect spot. Just a few hours from St. Louis, this lakeside destination is known for its vibrant atmosphere, water activities, and casual charm. Whether you want to lounge on a boat or explore the local bars and restaurants, Lake of the Ozarks offers a little bit of everything for an unforgettable weekend.
Why Lake of the Ozarks is Perfect for a Girls Weekend Trip
Lake of the Ozarks is all about unwinding and having fun with your best friends. The laid-back vibe makes it easy to forget about everything else, and there are plenty of things to do whether you’re a water sports enthusiast or prefer to relax on the shore. The area is full of waterfront resorts, ideal for gathering with friends and enjoying views of the lake. Plus, the local restaurants and bars offer great places to enjoy some live music or a sunset cocktail.
With so much to do in such a short drive from St. Louis, it’s a no-brainer when it comes to quick weekend trips that combine relaxation with adventure.
Top Things to Do in Lake of the Ozarks
- Boat Rentals & Water Activities: Rent a boat for the day and cruise along the lake. Whether you’re up for tubing, fishing, or just enjoying the stunning scenery, the options are endless on the water.
- The Bagnell Dam Strip: This popular strip is home to bars, restaurants, and shops, making it a perfect spot for a girls’ night out. Grab dinner at one of the local eateries, then hit up a live music bar for drinks and dancing.
- Shopping at Osage Beach: For those who love a good shopping spree, head over to Osage Beach. The outlet malls and local boutiques are perfect for finding something fun to bring home.
- Hike at Ha Ha Tonka State Park: If your group enjoys a little outdoor adventure, Ha Ha Tonka State Park is a must-visit. Explore the park’s unique castle ruins, hike the scenic trails, or just take in the panoramic views of the lake.
- Sunset at The Trophy Room: Located at the Osage Beach State Park, this is the ideal spot to end your day with a relaxing dinner and a stunning view of the sunset over the lake.
7. Kansas City, Missouri
Kansas City, Missouri, is an underrated gem for a quick girls weekend trip from St. Louis. Known for its iconic jazz scene, barbecue, and art scene, KC offers a blend of culture, great food, and live music that your best friends will love. Whether you’re looking to catch a show, indulge in Kansas City’s famous BBQ, or explore local boutiques, this city has something for everyone.
Why Kansas City is Perfect for a Girls Weekend Trip
Kansas City offers the best of both worlds: fun city adventures and relaxed vibes. The city’s walkable neighborhoods make it easy to explore, whether you’re hopping between historic landmarks, local breweries, or artsy districts. From quirky cafés to chic boutique hotels, Kansas City delivers a memorable experience without the big-city chaos, making it ideal for a stress-free girls’ getaway.
Top Things to Do in Kansas City
- Explore the Power & Light District: Known for its vibrant nightlife and entertainment options, the Power & Light District is a must-visit for a girls night out. With rooftop bars, local music venues, and fun restaurants, you can easily fill your weekend with excitement.
- Visit the Nelson-Atkins Museum of Art: Art lovers will appreciate a visit to the Nelson-Atkins Museum of Art, where world-class exhibits and impressive collections are free to explore. It’s perfect for an afternoon of culture and inspiration.
- BBQ Tour: Kansas City is famous for its barbecue, and what better way to enjoy it than on a food tour? Grab your best gals and explore some of the best BBQ joints in the city, from Joe’s Kansas City Bar-B-Que to Q39.
- Stroll Through the Country Club Plaza: The Country Club Plaza offers boutique shopping, charming cafes, and gorgeous Spanish-inspired architecture, making it the perfect spot to spend a leisurely afternoon.
- Catch Live Jazz at The Green Lady Lounge: Kansas City is the birthplace of jazz, and there’s no better way to experience it than by visiting one of the city’s iconic jazz bars like The Green Lady Lounge. Enjoy live music, cocktails, and a laid-back atmosphere perfect for a girls’ night out.
8. Chicago, Illinois
Chicago may be just a short flight or a few hours’ drive from St. Louis (you can also catch a train from St. Louis Union Station), but it’s packed with big-city energy and all the excitement you need for the ultimate girls weekend getaway. From vibrant neighborhoods to rooftop bars, world-class museums, and unique shopping districts, Chicago never disappoints.
Why Chicago is Perfect for a Girls Weekend Trip
With its iconic skyline, countless shopping opportunities, and a variety of activities, Chicago is the ultimate girls’ trip destination. Whether you’re into art, food, or shopping, Chicago has something to offer. You’ll enjoy an easy weekend escape with everything from top-notch restaurants to funky bars, all in a walkable, lively setting. Chicago also offers a great mix of budget-friendly options, making it perfect for any group.
Top Things to Do in Chicago
- Visit Millennium Park & Cloud Gate: The iconic Cloud Gate (also known as “The Bean”) in Millennium Park is a must-see and a great spot for group photos. Enjoy the public art, gardens, and the bustling atmosphere of downtown Chicago.
- Take a Chicago Architecture Boat Tour: Get a unique perspective of Chicago’s famous architecture with a boat tour along the Chicago River. It’s both educational and beautiful and perfect for groups who love learning about history and design.
- Shop on the Magnificent Mile: For some serious retail therapy, the Magnificent Mile offers everything from luxury brands to local boutiques. It’s one of the best places to shop for souvenirs or trendy pieces.
- Explore the Art Institute of Chicago: Known for its world-class collection of art, the Art Institute is a must-visit for those who appreciate culture and history. Spend the day exploring masterpieces from Monet to Grant Wood.
- Eat Deep-Dish Pizza: No trip to Chicago is complete without trying the iconic deep-dish pizza. Grab a slice (or an entire pie) from spots like Lou Malnati’s or Giordano’s for a true taste of the city.